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・Kleemann M. et al.: Cell Mol Life Sci. 2018 Nov 3 published.
"Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5."
Transfected cell: T98G, HCT 116, SKOV3 and SGBS cells
Transfected molecule: miRNA (ScreenFect™A)


・Onodera Y. et al.: PLoS One. 2018 Oct 1 published.
"Inflammation-associated miR-155 activates differentiation of muscular satellite cells."
Transfected cell: C2C12 cells
Transfected molecule: plasmid DNA (ScreenFect™A)


・Kobayashi T. et al.: BPB Reports. 2018 Sep 25; 1: 1-5.
"Methylmercury Induces Cytotoxicity through Inhibition of PTEN Activity by a Decrease in Its Solubility."
Transfected cell: SH-SY5Y cells
Transfected molecule: plasmid DNA


・Tatsumi Y. et al.: Neurosci Res. 2018 Sep 24 published.
"CMT type 2N disease-associated AARS mutant inhibits neurite growth that can be reversed by valproic acid."


・Karnati S. et al.: PLoS One. 2018 Sep 13 published.
"PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells."
Transfected cell: C22 cells
Transfected molecule: siRNA


・Pagano C. et al.: Sci Rep. 2018 Sep 4; 8(1) : 13180
"Evolution shapes the responsiveness of the D-box enhancer element to light and reactive oxygen species in vertebrates."
Transfected cell: Zebrafish PAC-2 and AB-9 cells, Cavefish EPA cells and HeLa cells
Transfected molecule: plasmid DNA


・Tomita T. et al.: The Journal of Biochemistry 2018 Aug 27 published.
"C1D is not directly involved in the repair of UV-damaged DNA but protects cells from oxidative stress by regulating gene expressions in human cell lines."


・Urai Y. et al.: Biochem Biophys Res Commun. 2018 Sep 10; 503(3): 2047-2053.
"Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation."
Transfected cell: Cos-7 cells
Transfected molecule: plasmid DNA (ScreenFect™A and ScreenFect™A plus)


・Honda T. et al.: J Cell Physiol. 2018 Aug 1 published.
"PDZRN3 regulates differentiation of myoblasts into myotubes through transcriptional and posttranslational control of Id2."
Transfected cell: C2C12 cells
Transfected molecule: plasmid DNA (ScreenFect™A plus)


・Osaki Y. et al.: Cell Death Dis. 2018 Jul 24; 9(8): 808
"Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II."
Transfected cell: HeLa cells
Transfected molecule: plasmid DNA and siRNA (ScreenFect™A)


・Yabe-Wada T. et al.: FEBS Lett. 2018 Aug; 592(15): 2647-2657.
"Crystal structure of the ligand‐free form of the Vps10 ectodomain of dimerized Sortilin at acidic pH."
Transfected cell: HEK293T
Transfected molecule: plasmid DNA (ScreenFect™A)


・Katsuyama M. et al.: Neurotoxicology. 2018 Jun 29 published.
"Clioquinol increases the expression of interleukin-8 by down-regulating GATA-2 and GATA-3"
Transfected cell: HEK293T
Transfected molecule: plasmid DNA


・Syring I. et al.: Oncology Letters 2018 Jun 25 published.
"The knockdown of the Mediator complex subunit MED15 restrains urothelial bladder cancer cells' malignancy"
Transfected cell: T24 and TCCSUP
Transfected molecule: siRNA


・Baba M. et al.: J Bone Miner Res. 2018 Jun 12 published.
"Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation."
Transfected cell: RAW264.7 cells
Transfected molecule: siRNA


・Senga S. et al.: Biochim Biophys Acta. 2018 Jun 12; 1863(9): 1057-1067.
"Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells."
Transfected cell: PC-3 and MDA-MB-231 cells
Transfected molecule: siRNA


・Kleemann M. et al.: Sci Rep. 2017 Feb 27; 7: 43207.
"MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells."
Transfected cell: T98G, SKOV3, and SGBS
Transfected molecule: microRNA


・Qian J. et al.: Chin J Cancer Res 2018; 30(2): 282-290.
"IGHG1 promotes motility likely through epithelial-mesenchymal transition in ovarian cancer"
Transfected cell: Ovarian Cancer cell (OC cell)
Transfected molecule: plasmid DNA, RNAi


・Kinoshita-Kikuta E. et al.: Biochim Biophys Acta. 2018 May 9; in press.
"Increase in constitutively active MEK1 species by introduction of MEK1 mutations identified in cancers."


・Tatekoshi Y. et al.: J Mol Cell Cardiol. 2018 May 4; 119: 138–146.
"Translational regulation by miR-301b upregulates AMP deaminase in diabetic hearts."


・Ishino T. et al.: Biomedical Research (Tokyo) 2018 Feb 13; 39 (2): 95–104.
"Establishment of protocol for preparation of gene-edited bovine ear-derived fibroblasts for somatic cell nuclear transplantation"
Transfected cell: HeLa cells
Transfected molecule: plasmid DNA


・Li LM. et al.: Curr Gene Ther. 2018 Apr 13 published.
"Transplantation of BDNF Gene Recombinant Mesenchymal Stem Cells and Adhesive Peptide-modified Hydrogel Scaffold for Spinal Cord Repair."
Transfected cell: MSCs
Transfected molecule: plasmid DNA


・Molla Mijanur R. et al.: Bioconjugate Chem. 2018 Mar 20; 29 (4): pp 992–999.
"One-Pot Parallel Synthesis of Lipid Library via Thiolactone Ring Opening and Screening for Gene Delivery."


・Matsumoto N. et al.: Biochem Biophys Res Commun. 2018 Apr 30; 499(1): 78-85.
"Treacher Collins syndrome 3 (TCS3)-associated POLR1C mutants are localized in the lysosome and inhibits chondrogenic differentiation."


・Koshizuka T. et al.: Sci Rep. 2018 Mar. 13; 8: 4447.
"Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases"
Transfected cell: Phoenix packaging cells
Transfected molecule: plasmid DNA for preparation and analysis of retrovirus


・Kobayashi Y. et al.: Biol. Pharm. Bull. 2018 Mar 1; 41: 374–382.
"Bisphenol A and Its Derivatives Induce Degradation of HIF-1alpha via the Lysosomal Pathway in Human Hepatocarcinoma Cell Line, Hep3B"
Transfected cell: Hep3B cells
Transfected molecule: siRNA


・Chadaeva Irina V. et al.: BMC Genomics 2018 Feb 9; 19(Suppl 3):0.
"Candidate SNP markers of reproductive potential are predicted by a significant change in the affinity of TATA-binding protein for human gene promoters"
Transfected cell: hTERT-BJ1 (human fibroblasts)
Transfected molecule: plasmid DNA


・Syring I. et al.: Annals of Diagnostic Pathology, 2018 Jun; 34: 18-26.
"The knockdown of the mediator complex subunit MED30 suppresses the proliferation and migration of renal cell carcinoma cells"


・Syring I. et al.: Anticancer Res. 2017 Dec; 37(12): 6685-6695.
"The Contrasting Role of the Mediator Subunit MED30 in the Progression of Bladder Cancer"


・Watanabe N. et al.: Biochem Biophys Res Commun. 2018 Jan 1; 495(1): 346-352.
"Dystonia-4 (DYT4)-associated TUBB4A mutants exhibit disorganized microtubule networks and inhibit neuronal process growth"


・Cao TT. et al.: Oncotarget. 2017 Jul 26; 8(39): 65957-65968.
"FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma"


・Saito A. et al.: J Neurochem. 2018 Jan; 144(1): 35-497.
"Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma"


・Flum M. et al.: J Cell Commun Signal. 2017 Sep 14.; published.
"miR-217-5p induces apoptosis by directly targeting PRKCI, BAG3, ITGAV and MAPK1 in colorectal cancer cells"


・Nakatsu Y. et al.: Pharmacological Reports. 2017 Jul 15; in press.
"Effect of acetaminophen on osteoblastic differentiation and migration of MC3T3-E1 cells"


・Fukuda SP. et al.: Dev Growth Differ. 2017 Jun; 59(5): 423-433.
"Cellular force assay detects altered contractility caused by a nephritis-associated mutation in nonmuscle myosin IIA"


・Jeannine S. et al.: ChemistryOpen. 2017 Jun 7; 6(4): 514-518.
"Synthesis of Wavelength-Shifting Fluorescent DNA and RNA with Two Photostable Cyanine–Styryl Dyes as the Base Surrogate Pair"


・Xing L. et al.: Int. Immunopharmacol. 2017 May 3; 48: 76-83.
"IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species"


・Maria J. G. et al.: Nanomedicine (Lond). 2017 Mar 19 published.
"Delivery of siRNA silencing P-gp in peptide-functionalized nanoparticles causes efflux modulation at the blood–brain barrier"


・Hirotsugu I. et al.: Methods. 2017 May 25 published.
"Use of the CRISPR-Cas9 system for genome editing in cultured Drosophila ovarian somatic cells"


・Uwada J. et al.: Cell. Signal. 2017 Apr 12; in press.
"Activation of muscarinic receptors prevents TNF-α-mediated intestinal epithelial barrier disruption through p38 MAPK"


・Tamaki T. et al.: Biochem Biophys Res. Commun. 2017 Apr 22; 486(1): 149-155.
"A novel transmembrane protein defines the endoplasmic reticulum stress-induced cell death pathway"


・Leitão RA. et al.: Mol. Neurobiol. 2017 Mar 10 published.
"Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior"


・Eun K. et al.: Biochem Biophys Res. Commun. 2017 Apr 29; 486(2): 564-570.
"A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells"


・Nakamura T. et al.: Genes Cell 2017 Apr 22; 22(4): 392-405.
"Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms"


・Schoellhorn M. et al.: Biotechnol Prog. 2017 Apr 3 published.
"miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins"


・Yaguchi A. et al.: Int. J. Hematol. 2017 Apr 4 published.
"EP300-ZNF384 fusion gene product up-regulates GATA3 gene expression and induces hematopoietic stem cell gene expression signature in B-cell precursor acute lymphoblastic leukemia cells"


・Shan Z. et al.: Sci Rep. 2017 Feb 27; 7: 43207.
"Mammalian TRAPPIII Complex positively modulates the recruitment of Sec13/31 onto COPII vesicles"


・Heidi-Kristin W. et al.: Beilstein J. Org. Chem. 2017 Jan 20; 13: 127-137.
"A postsynthetically 2’-“clickable” uridine with arabino configuration and its application for fluorescent labeling and imaging of DNA"


・Kinoshita E. et al.: Electrophoresis. 2017 Feb 23 published
"Specific glutamic acid residues in targeted proteins induce exaggerated retardations in Phos-tag SDS-PAGE migration"


・Vijayan V. et al.: J. Immunol. 2017 Feb 8 published
"A New Immunomodulatory Role for Peroxisomes in Macrophages Activated by the TLR4 Ligand Lipopolysaccharide"


・Okada M. et al.:Am. J. Physiol. Cell Physiol. 2016 Dec 21 published.
"Canstatin stimulates migration of rat cardiac fibroblasts via secretion of matrix metalloproteinase-2"


・Xiang C. et al.:Sci Rep. 2016 Nov 17; 6: 37310.
"The androgen-induced protein AIbZIP facilitates proliferation of prostate cancer cells through downregulation of p21 expression"


・Bapon D. et al.:Biochem. Biophysical Res. Com. 2016 Nov 17; in press.
"Identification of functional bitter taste receptors and their antagonist in chickens"


・Carol PY L. et al.:J. Cell. Biochem. 2016 Nov 15; in press.
"Genome-Wide Transcriptome Profiling of the Neoplastic Giant Cell Tumor of Bone Stromal Cells by RNA Sequencing"


・Kaneko M.et al.:Sci Rep. 2016 Aug 3;6:30955.
"Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation."


・Kimura N.et.al.:Am J Pathol. 2016 Jul;186(7):1952-66.
"Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Is Required for Alteration in β-Amyloid Precursor Protein Metabolism."


・Nakano N.et.al.:Neurosci Lett. 2016 May 27;622:88-94 
"NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3."


・Yabe-Wada T.et.al.:TLR siSci Rep. 2016 May 25;6:26566.
"TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin."


・Tateishi K.et.al.:Clin Cancer Res. 2016 Sep 1;22(17):4452-65.
"Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma."


・Tani R.et.al.:Epigenetics. 2016 Mar 28;11(4):288-302. 
"Linker histone variant H1T targets rDNA repeats."


・Miyake A.et.al.:J Virol. 2016 Apr 14;90(9):4832-7.
"Novel feline leukemia virus interference group based on env gene"


・Ogiwara K.et.al.:Biol Reprod. 2016 Feb 10;94(3):64.
"A Dual Role for Melatonin in Medaka Ovulation: Ensuring Prostaglandin Synthesis and Actin Cytoskeleton Rearrangement in Follicular Cells."


・Ukita M.et.al.:J Cell Biochem. 2016 Jun;117(6):1419-28.
"Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells."


・Shudo Y.et.al.:Life Sci. 2015 Dec 15;143:174-81.
"Pituitary adenylate cyclase-activating polypeptide is regulated by alternative splicing of transcriptional repressor REST/NRSF in nerve injury."


・Katsura A.et.al.:Genes Cells. 2016 Jan;21(1):99-116.
"MicroRNA-31 is a positive modulator of endothelial-mesenchymal transition and associated secretory phenotype induced by TGF-β."


・Onoshima D.et.al.:Adv Drug Deliv Rev. 2015 Dec 1;95:2-14.
"Onoshima D.et.al.:Adv Drug Deliv Rev. 2015 Dec 1;95:2-14."


・Ito J.et.al.:J Virol. 2015 Nov 18;90(3):1470-85. 
"Ancestral Mutations Acquired in Refrex-1, a Restriction Factor against Feline Retroviruses, during its Cooption and Domestication."


・Asada R.et.al.:Sci Rep. 2015 Nov 16;5:16580.
"IRE1α-XBP1 is a novel branch in the transcriptional regulation of Ucp1 in brown adipocytes."


・Cui M.et.al.:Sci Rep. 2015 Nov 12;5:16455.
"OASIS modulates hypoxia pathway activity to regulate bone angiogenesis."


・Sugawara Y.et.al.:FEBS J. 2015 Sep;282(17):3334-47.
"Clostridium botulinum type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3."


・Murakawa T.et.al.:Nat Commun. 2015 Jul 6;6:7527.
"Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation."


・Neo SH.et.al.:Mol Cell Biol. 2015 Aug;35(16):2851-63.
"TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification."


・Hirose N.et.al.:Biochem Biophys Res Commun. 2015 May 1;460(2):464-8.
"Bitter taste receptor T2R1 activities were compatible with behavioral sensitivity to bitterness in chickens."


・Sawamura R.et.al.:Biochem Biophys Res Commun. 2015 Mar 6;458(2):387-91.
"The role of G-protein-coupled receptor 120 in fatty acids sensing in chicken oral tissues."


・Matsumura T.et.al.:Nat Commun. 2015 Feb 17;6:6255.
"Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity"


・Nga BT.et.al.:Biosci Biotechnol Biochem. 2015;79(4):587-97.
"Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2α."

・Kato Y.et.al.:Sci Rep. 2014 Aug 1;4:5924.
"A cancer-specific monoclonal antibody recognizes the aberrantly glycosylated podoplanin."


・Ihara H.et.al.:Biochem Biophys Res Commun. 2014 Jul 25;450(2):953-60.
"Cloning, expression and characterization of Bombyx mori α1,6-fucosyltransferase."


・Kim JK.et.al.:Mol Biol Rep. 2014 Sep;41(9):5903-11.
"Rab3a promotes brain tumor initiation and progression."


・Wakimoto H.et.al.:Clin Cancer Res. 2014 Jun 1;20(11):2898-909.
"Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas."


・Watanabe S.et.al.:J Vet Med Sci. 2014 Apr;76(4):553-7.
"Notch2 transduction by feline leukemia virus in a naturally infected cat."


・Liu X.et.al.:Cancer Med. 2013 Dec;2(6):803-14.
"Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1."


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